THRB antibody (Middle Region)

Catalog No. ABIN2780345

This Rabbit Polyclonal antibody specifically detects THRB in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Cow and Sheep.

Quick Overview for THRB antibody (Middle Region) (ABIN2780345)

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Reactivity: Human, Mouse, Rat, Horse, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Cow, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THRB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-THRB Antibody

Binding Specificity: Middle Region

Sequence: YQDSFLLAFE HYINYRKHHV THFWPKLLMK VTDLRMIGAC HASRFLHMKV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against THRB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human THRB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 461 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Alternative Name: THRB

Background: THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Alias Symbols: ERBA-BETA, ERBA2, GRTH, MGC126109, MGC126110, NR1A2, THR1, THRB1, THRB2, PRTH, C-ERBA-2, C-ERBA-BETA
Protein Interaction Partner: NSD1, NCOA1, RANBP9, NCOR1, RXRA, THRB, MMS19, ADAT3, NCOA2, C1D, NCOA3, ATF2, ANP32A, SUMO1, SUMO2, ROBO4, MED21, HMGN3, EIF3I, NRIP1, RXRG, RXRB, CAMK2B, TBL1XR1, NCOR2, HDAC3, SMC1A, XRCC5, TBL1X, PRKDC, LIG3, HSPA4, GPS2, XRCC6, PARP1, LRIF1, SRC, PSM
Protein Size: 461

Molecular Weight: 53 kDa

Gene ID: 7068

NCBI Accession: NM_000461, NP_000452

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound