FOXO1 antibody (N-Term)

Catalog No. ABIN2780391

This Rabbit Polyclonal antibody specifically detects FOXO1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Pig, Dog and Saccharomyces cerevisiaeand has been mentioned in 1 publication.

Quick Overview for FOXO1 antibody (N-Term) (ABIN2780391)

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXO1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FOXO1 Antibody

Binding Specificity: N-Term

Sequence: MAEAPQVVEI DPDFEPLPRP RSCTWPLPRP EFSQSNSATS SPAPSGSAAA

Predicted Reactivity: Cow: 92%, Dog: 92%, Human: 100%, Mouse: 85%, Pig: 92%, Rat: 85%, Yeast: 85%

Characteristics: This is a rabbit polyclonal antibody against FOXO1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FOXO1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 655 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FOXO1 antibody (ABIN2780391)

Hsu, Hu: "Energy-regulated molecules maintain young status in the trophocytes and fat cells of old queen honeybees." in: Biogerontology, Vol. 15, Issue 4, pp. 389-400, (2014) (PubMed).

Target Details for FOXO1

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Alternative Name: FOXO1A

Background: FOXO1A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of FOXO1A has not yet been determined, however, it may play a role in myogenic growth and differentiation. Translocation of FOXO1A gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
Alias Symbols: FKH1, FKHR, FOXO1A
Protein Interaction Partner: EP300, AKT1, MST1, SIRT1, FHL2, ATG7, IRF3, FSHR, ESR1, Ubc, TXNRD1, RARA, MDM2, NLK, SKP2, SIRT2, STUB1, CREBBP, PML, LRPPRC, HOXA11, HNF4A, PARP1, DYRK1A, THRB, CSNK1G1, YWHAG, GSK3B, SMAD3, PAK1, PPARG, YWHAZ, SMAD4, AR, G6PC, SRC, CEBPB, FOXG1, HOXA10
Protein Size: 655

Molecular Weight: 70 kDa

Gene ID: 2308

NCBI Accession: NM_002015, NP_002006

UniProt: Q12778

Pathways: PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling