NKX3-1 antibody (Middle Region)

Catalog No. ABIN2780751

This Rabbit Polyclonal antibody specifically detects NKX3-1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for NKX3-1 antibody (Middle Region) (ABIN2780751)

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NKX3-1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NKX3-1 Antibody

Binding Specificity: Middle Region

Purpose: NKX3-1 Antibody - middle region

Sequence: FSHQKYLSAP ERAHLAKNLK LTETQVKIWF QNRRYKTKRK QLSSELGDLE

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against NKX3-1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NKX3-1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38751-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Alternative Name: NKX3-1

Background:

Background Information: The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: NK3 homeobox 1

Alternative Symbols: NKX3, BAPX2, NKX3A, NKX3.1

Protein Name: Homeobox protein Nkx-3.1

Molecular Weight: 26kDa

Gene ID: 4824

NCBI Accession: NP_006158

UniProt: Q99801

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus