SLCO1B1 antibody (Middle Region)

Catalog No. ABIN2781625

Product Details anti-SLCO1B1 Antibody

Target: SLCO1B1 (Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1))

Binding Specificity: Middle Region

Reactivity: Human, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLCO1B1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IILIYAMKKK YQEKDINASE NGSVMDEANL ESLNKNKHFV PSAGADSETH

Predicted Reactivity: Cow: 86%, Human: 100%, Pig: 79%

Characteristics: This is a rabbit polyclonal antibody against SLCO1B1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SLCO1B1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 691 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SLCO1B1

Target: SLCO1B1 (Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1))

Alternative Name: SLCO1B1 (SLCO1B1 Products)

Synonyms: HBLRR antibody, LST-1 antibody, LST1 antibody, OATP-C antibody, OATP1B1 antibody, OATP2 antibody, OATPC antibody, SLC21A6 antibody, SLCO1B1 antibody, solute carrier organic anion transporter family member 1B1 antibody, SLCO1B1 antibody, LOC100011628 antibody, LOC100448597 antibody

Background: This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.
Alias Symbols: LST-1, MGC133282, OATP-C, OATP1B1, OATP2, SLC21A6, LST1, HBLRR, OATPC
Protein Size: 691

Molecular Weight: 76 kDa

Gene ID: 10599

NCBI Accession: NM_006446, NP_006437

UniProt: Q9Y6L6