Presenilin 2 antibody (C-Term)

Catalog No. ABIN2781803

This Rabbit Polyclonal antibody specifically detects Presenilin 2 in WB. It exhibits reactivity toward Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse and Rabbit.

Quick Overview for Presenilin 2 antibody (C-Term) (ABIN2781803)

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivity: Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Presenilin 2 Antibody

Binding Specificity: C-Term

Sequence: TAQERNEPIF PALIYSSAMV WTVGMAKLDP SSQGALQLPY DPEMEEDSYD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Psen2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Rat Psen2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 448 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Alternative Name: Psen2

Background: This gene mutations in human homolog responsible for chromosome 1-linked familial Alzheimer's disease, expression increased during brain development but decreased in the adult.
Alias Symbols: -
Protein Size: 448

Molecular Weight: 49 kDa

Gene ID: 81751

NCBI Accession: NM_031087, NP_112349

UniProt: O88777

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway