HBEGF antibody (N-Term)

Catalog No. ABIN2782149

The Rabbit Polyclonal anti-HBEGF antibody is suitable to detect HBEGF in samples from Human, Mouse, Rat, Cow, Pig, Dog, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for HBEGF antibody (N-Term) (ABIN2782149)

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HBEGF antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HBEGF Antibody

Binding Specificity: N-Term

Purpose: HBEGF Antibody - N-terminal region

Sequence: FLAAVLSALV TGESLERLRR GLAAGTSNPD PPTVSTDQLL PLGGGRDRKV

Predicted Reactivity: Cow: 100%, Dog: 86%, Guinea Pig: 79%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HBEGF. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human HBEGF

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45201-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HBEGF

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Alternative Name: HBEGF

Background:

Background Information: HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.

Gene Name: heparin-binding EGF-like growth factor

Alternative Symbols: DTR, DTS, DTSF, HEGFL

Protein Name: Proheparin-binding EGF-like growth factor

Molecular Weight: 22kDa

Gene ID: 1839

NCBI Accession: NP_001936

UniProt: Q99075

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway