GNS antibody (C-Term)

Catalog No. ABIN2782155

The Rabbit Polyclonal anti-GNS antibody is suitable to detect GNS in samples from Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Goat, Guinea Pig, Horse, Rabbit and Dog. It has been validated for WB and IHC.

Quick Overview for GNS antibody (C-Term) (ABIN2782155)

Target: GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Goat, Guinea Pig, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GNS Antibody

Binding Specificity: C-Term

Purpose: GNS Antibody - C-terminal region

Sequence: PILRGASNLT WRSDVLVEYQ GEGRNVTDPT CPSLSPGVSQ CFPDCVCEDA

Predicted Reactivity: Cow: 100%, Dog: 93%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against GNS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GNS

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45217-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GNS

Target: GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))

Alternative Name: GNS

Background:

Background Information: GNS is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparin sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder ucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.

Gene Name: Glucosamine (N-acetyl)-6-sulfatase

Alternative Symbols: G6S

Protein Name: N-acetylglucosamine-6-sulfatase

Molecular Weight: 62kDa

Gene ID: 2799

NCBI Accession: NP_002067

UniProt: P15586

Pathways: Glycosaminoglycan Metabolic Process