TAPBP antibody (N-Term)

Catalog No. ABIN2782217

The Rabbit Polyclonal anti-TAPBP antibody (ABIN2782217) specifically detects TAPBP in WB and IHC. The antibody is reactive with Human, Mouse, Sheep, Pig, Rat, Horse, Dog and Rabbit samples.

Quick Overview for TAPBP antibody (N-Term) (ABIN2782217)

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Reactivity: Human, Mouse, Sheep, Pig, Rat, Horse, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAPBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TAPBP Antibody

Binding Specificity: N-Term

Purpose: TAPBP Antibody - N-terminal region

Sequence: GKGLAKRPGA LLLRQGPGEP PPRPDLDPEL YLSVHDPAGA LQAAFRRYPR

Predicted Reactivity: Dog: 93%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 93%, Rat: 86%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against TAPBP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TAPBP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45436-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TAPBP

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Alternative Name: TAPBP

Background:

Background Information: TAPBP is a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum.

Gene Name: TAP binding protein (tapasin)

Alternative Symbols: TPN, TAPA, TPSN, NGS17

Protein Name: Tapasin

Molecular Weight: 30kDa

Gene ID: 6892

NCBI Accession: NP_757345

UniProt: O15533