PSMB8 antibody (N-Term)

Catalog No. ABIN2782484

Product Details anti-PSMB8 Antibody

Target: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MLIGTPTPRD TTPSSWLTSS LLVEAAPLDD TTLPTPVSSG CPGLEPTEFF

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against PSMB8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PSMB8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMB8

Target: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Alternative Name: PSMB8 (PSMB8 Products)

Synonyms: ALDD antibody, D6S216 antibody, D6S216E antibody, JMP antibody, LMP7 antibody, NKJO antibody, PSMB5i antibody, RING10 antibody, ATP6V0D2 antibody, lmp7 antibody, prosome antibody, macropain antibody, Lmp-7 antibody, Lmp7 antibody, Ring10 antibody, proteasome subunit beta 8 antibody, proteasome subunit beta 8A antibody, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) antibody, PSMB8 antibody, psmb8a antibody, Psmb8 antibody

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.
Protein Interaction Partner: IKBKG, PSMB7, PSMB6, PSMB5, PSMB4, PSMB2, PSMB1, PSMA6, PSMA5, PSMA4, PSMA3, PSMA1, HNRNPM, EIF4G1, GCN1L1, CCT2, RPP38, DHX38, PSMA2, PSMA7, PSMA8, USP9X, PSMD8, PSMC5, PSMC4, PSMC3, PSMC2, PSMC1, PSMB3, UBC, PSME2, PSME1, HCVgp1, POMP, TAP2, TAP1, PSMB1
Protein Size: 272

Molecular Weight: 29 kDa

Gene ID: 5696

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA