CPT1B antibody (Middle Region)

Catalog No. ABIN2782633

This Rabbit Polyclonal antibody specifically detects CPT1B in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow, Sheep and Zebrafish (Danio rerio). It has been mentioned in 4+ publications

Quick Overview for CPT1B antibody (Middle Region) (ABIN2782633)

Target: CPT1B (Carnitine Palmitoyltransferase 1B (Muscle) (CPT1B))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPT1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CPT1B Antibody

Binding Specificity: Middle Region

Purpose: CPT1B Antibody - middle region

Sequence: DLEMQFQRIL DDPSPPQPGE EKLAALTAGG RVEWAQARQA FFSSGKNKAA

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against CPT1B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CPT1B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46444-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CPT1B antibody (ABIN2782633)

Fiserova, Trinh, Elkalaf, Vacek, Heide, Martinkova, Bechynska, Kosek, Hajslova, Fiser, Tousek, Polak: "Isoprenaline modified the lipidomic profile and reduced β-oxidation in HL-1 cardiomyocytes: In vitro model of takotsubo syndrome." in: Frontiers in cardiovascular medicine, Vol. 9, pp. 917989, (2022) (PubMed).

Jiang, Ma, Li, Cao, Wang, Zhang, Liu: "Effects of neonatal dexamethasone administration on cardiac recovery ability under ischemia-reperfusion in 24-wk-old rats." in: Pediatric research, Vol. 80, Issue 1, pp. 128-35, (2016) (PubMed).

Li, Liu, Ma, Guan, Cao, Tian, Zhang: "Enhancement of Glucose Metabolism via PGC-1α Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia." in: Frontiers in physiology, Vol. 7, pp. 219, (2016) (PubMed).

Wolf-Johnston, Hanna-Mitchell, Buffington, Shinde, Roppolo, Mayer, Birder: "Alterations in the non-neuronal acetylcholine synthesis and release machinery in esophageal epithelium." in: Life sciences, Vol. 91, Issue 21-22, pp. 1065-9, (2012) (PubMed).

Target Details for CPT1B

Target: CPT1B (Carnitine Palmitoyltransferase 1B (Muscle) (CPT1B))

Alternative Name: CPT1B

Background:

Background Information: The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-

Gene Name: Carnitine palmitoyltransferase 1B (muscle)

Alternative Symbols: CPTI, CPT1M, MCPT1, CPT1-M, CPTI-M, M-CPT1, MCCPT1

Protein Name: Carnitine O-palmitoyltransferase 1, muscle isoform

Molecular Weight: 88 kDa

Gene ID: 1375

NCBI Accession: NP_004368

UniProt: Q92523

Pathways: AMPK Signaling, Monocarboxylic Acid Catabolic Process