POLD2 antibody (N-Term)

Catalog No. ABIN2783466

This Rabbit Polyclonal antibody specifically detects POLD2 in WB. It exhibits reactivity toward Human, Rat, Mouse, Rabbit, Cow, Guinea Pig, Dog and Horse.

Quick Overview for POLD2 antibody (N-Term) (ABIN2783466)

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Guinea Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-POLD2 Antibody

Binding Specificity: N-Term

Sequence: LREVSEEHNL LPQPPRSKYI HPDDELVLED ELQRIKLKGT IDVSKLVTGT

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against POLD2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human POLD2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 469 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for POLD2

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Alternative Name: POLD2

Background: This protein is a DNA polymerase delta complex ,it involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen, the multisubunit replication factor C, and the 4 subunit polymerase complex: POLD1, POLD2, POLD3, and POLD4The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA, MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1 (MIM 174761), POLD2, POLD3 (MIM 611415), and POLD4 (MIM 611525) (Liu and Warbrick, 2006 [PubMed 16934752]).[supplied by OMIM].
Alias Symbols: -
Protein Interaction Partner: UBC, SPRTN, FOXK1, FAM129A, XRN1, POLD1, MMS19, POLD4, CCHCR1, SOX12, EP300, UBD, BBLF2-BBLF3, POLD3, PCNA, POLDIP3, POLDIP2, KCTD13, WRNIP1, LSM6, WRN, CDK2, CDKN1A,
Protein Size: 469

Molecular Weight: 51 kDa

Gene ID: 5425

NCBI Accession: NM_006230, NP_006221

UniProt: P49005

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA