Protocadherin gamma Subfamily A, 4 (PCDHGA4) (N-Term) antibody

Details for Product No. ABIN2783724
Antigen
Epitope
N-Term
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
4
3
2
Host
Rabbit
3
1
Clonality
Polyclonal
Application
Western Blotting (WB)
4
1
Options
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHGA4
Blocking Peptide Blocking peptide for this product available: ABIN981459
Sequence GDPVRSGTAR ILIILVDTND NAPVFTQPEY HVSVRENVPV GTRLLTVKAT
Predicted Reactivity Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%
Characteristics This is a rabbit polyclonal antibody against PCDHGA4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Antigen
Alternative Name PCDHGA4 (PCDHGA4 Antibody Abstract)
Background PCDHGA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHGA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Alias Symbols: PCDH-GAMMA-A4
Protein Size: 820
Molecular Weight 86 kDa
Gene ID 56111
NCBI Accession NM_032053, NP_114442
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 820 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Image no. 1 for anti-Protocadherin gamma Subfamily A, 4 (PCDHGA4) (N-Term) antibody (ABIN2783724) WB Suggested Anti-PCDHGA4 Antibody Titration: 0.2-1 ug/ml Positive Control: Hela c...