SPACA1 antibody (N-Term)

Catalog No. ABIN2783998

This Rabbit Polyclonal antibody specifically detects SPACA1 in WB. It exhibits reactivity toward Human.

Quick Overview for SPACA1 antibody (N-Term) (ABIN2783998)

Target: SPACA1 (Sperm Acrosome Associated 1 (SPACA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPACA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SPACA1 Antibody

Binding Specificity: N-Term

Purpose: SPACA1 Antibody - N-terminal region

Sequence: TENNDSETAE NYAPPETEDV SNRNVVKEVE FGMCTVTCGI GVREVILTNG

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against SPACA1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SPACA1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP49984-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPACA1

Target: SPACA1 (Sperm Acrosome Associated 1 (SPACA1))

Alternative Name: SPACA1

Background:

Background Information: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively.

Gene Name: Sperm acrosome associated 1

Alternative Symbols: SAMP32

Protein Name: Sperm acrosome membrane-associated protein 1

Molecular Weight: 32kDa

Gene ID: 81833

NCBI Accession: NP_112222

UniProt: Q9HBV2