DISP1 antibody (Middle Region)

Catalog No. ABIN2784069

The Rabbit Polyclonal anti-DISP1 antibody is suitable to detect DISP1 in samples from Human, Mouse, Rat, Rabbit, Zebrafish (Danio rerio), Horse and Pig. It has been validated for WB.

Quick Overview for DISP1 antibody (Middle Region) (ABIN2784069)

Target: DISP1 (Dispatched Homolog 1 (DISP1))

Reactivity: Human, Mouse, Rat, Rabbit, Zebrafish (Danio rerio), Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DISP1 Antibody

Binding Specificity: Middle Region

Purpose: DISP1 Antibody - middle region

Sequence: FVLCDVWNYT KFDKPHAETS ETVSITLQHA ALSMFVTSFT TAAAFYANYV

Predicted Reactivity: Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 100%, Rat: 86%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against DISP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DISP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50142-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DISP1

Target: DISP1 (Dispatched Homolog 1 (DISP1))

Alternative Name: DISP1

Background:

Background Information: DISP1 functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo.

Gene Name: Dispatched homolog 1 (Drosophila)

Alternative Symbols: DISPA

Protein Name: Protein dispatched homolog 1

Molecular Weight: 171 kDa

Gene ID: 84976

NCBI Accession: NP_116279

UniProt: Q96F81

Pathways: Hedgehog Signaling