DISP1 antibody (Middle Region)

Catalog No. ABIN2784069

Product Details anti-DISP1 Antibody

Target: DISP1 (Dispatched Homolog 1 (DISP1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FVLCDVWNYT KFDKPHAETS ETVSITLQHA ALSMFVTSFT TAAAFYANYV

Predicted Reactivity: Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 100%, Rat: 86%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against DISP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DISP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1524 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DISP1

Target: DISP1 (Dispatched Homolog 1 (DISP1))

Alternative Name: DISP1 (DISP1 Products)

Synonyms: DISP1 antibody, DISPA antibody, 1190008H24Rik antibody, DispA antibody, con antibody, zgc:111866 antibody, dispatched antibody, dispatched RND transporter family member 1 antibody, dispatched homolog 1 (Drosophila) antibody, CpipJ_CPIJ008642 antibody, DISP1 antibody, Disp1 antibody, disp1 antibody

Background: DISP1 functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo.
Alias Symbols: DISPA, DKFZP434I0428, FLJ43740, MGC104180, MGC13130, MGC16796
Protein Interaction Partner: LAPTM5, UBC,
Protein Size: 1524

Molecular Weight: 171 kDa

Gene ID: 84976

NCBI Accession: NM_032890, NP_116279

UniProt: Q96F81

Pathways: Hedgehog Signaling