CRYM antibody (N-Term)

Catalog No. ABIN2784721

This Rabbit Polyclonal antibody specifically detects CRYM in WB. It exhibits reactivity toward Human and Cow.

Quick Overview for CRYM antibody (N-Term) (ABIN2784721)

Target: CRYM (Crystallin, mu (CRYM))

Reactivity: Human, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYM antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRYM Antibody

Binding Specificity: N-Term

Purpose: CRYM Antibody - N-terminal region

Sequence: ALTTKLVTFY EDRGITSVVP SHQATVLLFE PSNGTLLAVM DGNVITAKRT

Predicted Reactivity: Cow: 79%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CRYM. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CRYM

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP51981-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CRYM

Target: CRYM (Crystallin, mu (CRYM))

Alternative Name: CRYM

Background:

Background Information: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Name: Crystallin, mu

Alternative Symbols: THBP, DFNA40

Protein Name: Thiomorpholine-carboxylate dehydrogenase

Molecular Weight: 34kDa

Gene ID: 1428

NCBI Accession: NP_001879

UniProt: Q14894

Pathways: Hormone Transport, Sensory Perception of Sound