JAK3 antibody (N-Term)

Catalog No. ABIN2785644

This anti-JAK3 antibody is a Rabbit Polyclonal antibody detecting JAK3 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Horse, Pig and Guinea Pig.

Quick Overview for JAK3 antibody (N-Term) (ABIN2785644)

Target: JAK3 (Janus Kinase 3 (JAK3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAK3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-JAK3 Antibody

Binding Specificity: N-Term

Sequence: APPSEETPLI PQRSCSLLST EAGALHVLLP ARGPGPPQRL SFSFGDHLAE

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 92%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against JAK3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human JAK3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for JAK3

Target: JAK3 (Janus Kinase 3 (JAK3))

Alternative Name: JAK3

Background: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Alias Symbols: JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN
Protein Size: 619

Molecular Weight: 68 kDa

Gene ID: 3718

NCBI Accession: NM_000215, NP_000206

UniProt: Q8N1E8

Pathways: JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response