RHOB antibody (Middle Region)

Catalog No. ABIN2785839

Product Details anti-RHOB Antibody

Target: RHOB (Ras Homolog Gene Family, Member B (RHOB))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Goat, Horse, Pig, Sheep, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RHOB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CPNVPIILVA NKKDLRSDEH VRTELARMKQ EPVRTDDGRA MAVRIQAYDY

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 79%, Rat: 100%, Sheep: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against RHOB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RHOB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 196 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RHOB

Target: RHOB (Ras Homolog Gene Family, Member B (RHOB))

Alternative Name: RHOB (RHOB Products)

Synonyms: ARH6 antibody, ARHB antibody, MST081 antibody, MSTP081 antibody, RHOH6 antibody, AA017882 antibody, Arh6 antibody, Arhb antibody, RHO antibody, arha antibody, rhoa antibody, wu:fj42e08 antibody, zgc:92206 antibody, rhob antibody, xrhob antibody, ras homolog family member B antibody, ras homolog gene family, member Ab antibody, ras homolog family member B S homeolog antibody, RHOB antibody, Rhob antibody, rhoab antibody, rhob.S antibody

Background: RHOB mediates apoptosis in neoplastically transformed cells after DNA damage.RHOB is not essential for development but affects cell adhesion and growth factor signaling in transformed cells.RHOB plays a negative role in tumorigenesis as deletion causes tumor formation. RHOB is involved in intracellular protein trafficking of a number of proteins.RHOB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.RHOB is also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
Alias Symbols: ARH6, ARHB, MST081, MSTP081, RHOH6
Protein Interaction Partner: RAC1, MDM2, UBC, CORO1C, LAMTOR3, ILF2, HNRNPU, TNFAIP1, ELAVL1, ARHGEF3, RHPN2, PPP2CA, ARHGDIG, PDE6D, PGGT1B, FNTA, CIT,
Protein Size: 196

Molecular Weight: 22 kDa

Gene ID: 388

NCBI Accession: NM_004040, NP_004031

UniProt: P62745