TBK1 antibody (Middle Region)

Catalog No. ABIN2785953

The Rabbit Polyclonal anti-TBK1 antibody (ABIN2785953) specifically detects TBK1 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Guinea Pig and Zebrafish (Danio rerio) samples.

Quick Overview for TBK1 antibody (Middle Region) (ABIN2785953)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TBK1 Antibody

Binding Specificity: Middle Region

Sequence: QEGTHPKDRN VEKLQVLLNC MTEIYYQFKK DKAERRLAYN EEQIHKFDKQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against TBK1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TBK1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 729 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Alternative Name: TBK1

Background: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitinat
Alias Symbols: FLJ11330, NAK, T2K
Protein Interaction Partner: UBC, Trim11, AZI2, TBK1, TANK, TBKBP1, EGFR, TMEM173, TRAF3, EXOC2, MIB1, LATS2, ANKRD28, DDX58, SYK, TRAF3IP2, TOMM70A, STX11, PROS1, IRF3, HSP90AA1, XIAP, RNF11, YWHAE, APP, NFKBIA, IKBKG, TRAF2, MAVS, OPTN, SRC, RELA, TICAM1, MBP, IRF7, IKBKE, HERC2, T
Protein Size: 729

Molecular Weight: 84 kDa

Gene ID: 29110

NCBI Accession: NM_013254, NP_037386

UniProt: Q9UHD2

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome