TRIB3 antibody (N-Term)

Catalog No. ABIN2787258

This Rabbit Polyclonal antibody specifically detects TRIB3 in WB. It exhibits reactivity toward Human, Cow, Sheep and Pig.

Quick Overview for TRIB3 antibody (N-Term) (ABIN2787258)

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Reactivity: Human, Cow, Sheep, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIB3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRIB3 Antibody

Binding Specificity: N-Term

Sequence: KNNRMSANND HFLTPTWQQM RATPLAAPAG SLSRKKRLEL DDNLDTERPV

Predicted Reactivity: Cow: 91%, Human: 100%, Pig: 91%, Sheep: 91%

Characteristics: This is a rabbit polyclonal antibody against TRIB3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human TRIB3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIB3

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Alternative Name: TRIB3

Background: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants.
Alias Symbols: NIPK, SINK, TRB3, SKIP3, C20orf97
Protein Size: 385

Molecular Weight: 42 kDa

Gene ID: 57761

NCBI Accession: NM_001301201, NP_001288130

UniProt: J3KR25

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha