PPHLN1 antibody (N-Term)

Catalog No. ABIN2787411

The Rabbit Polyclonal anti-PPHLN1 antibody (ABIN2787411) specifically detects PPHLN1 in WB. The antibody is reactive with Human, Mouse, Rat, Pig, Rabbit, Dog and Horse samples.

Quick Overview for PPHLN1 antibody (N-Term) (ABIN2787411)

Target: PPHLN1 (Periphilin 1 (PPHLN1))

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPHLN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PPHLN1 Antibody

Binding Specificity: N-Term

Purpose: PPHLN1 Antibody - N-terminal region

Sequence: MAYRRDEMWS EGRYEYERIP RERAPPRSHP SDGYNRLVNI VPKKPPLLDR

Predicted Reactivity: Dog: 92%, Horse: 80%, Human: 100%, Mouse: 92%, Pig: 85%, Rabbit: 85%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against PPHLN1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PPHLN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57819-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PPHLN1

Target: PPHLN1 (Periphilin 1 (PPHLN1))

Alternative Name: PPHLN1

Background:

Background Information: The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene Name: Periphilin 1

Alternative Symbols: CR, HSPC206, HSPC232

Protein Name: Periphilin-1

Molecular Weight: 43kDa

Gene ID: 51535

NCBI Accession: NP_958923

UniProt: Q8NEY8