BAX antibody (N-Term)

Catalog No. ABIN2787858

This Rabbit Polyclonal antibody specifically detects BAX in WB. It exhibits reactivity toward Human, Mouse, Rat, Pig, Cow, Rabbit, Dog, Sheep, Horse and Guinea Pig.

Quick Overview for BAX antibody (N-Term) (ABIN2787858)

Target: BAX (BCL2-Associated X Protein (BAX))

Reactivity: Human, Mouse, Rat, Pig, Cow, Rabbit, Dog, Sheep, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BAX Antibody

Binding Specificity: N-Term

Sequence: IMKTGALLLQ GFIQDRAGRM GGEAPELALD PVPQDASTKK LSECLKRIGD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 91%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against BAX. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BAX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 218 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Alternative Name: BAX

Background: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Alias Symbols: BCL2L4
Protein Interaction Partner: CYCS, ZBTB24, UBC, CASP9, CASP8, CASP7, CASP3, BCL2L1, BCL2, CLU, MDM2, MCL1, BAX, BAG3, YWHAB, VCP, CRYAB, CRYAA, BAK1, XIAP, TP53, KCNA3, HSPA4, XRCC6, XRCC5, HDAC6, BAD, PSMC5, PSMC3, PARK7, UHRF2, RNF144B, OYE2, TOMM22, TOMM40, MEPCE, MOAP1, BBC3, PPP
Protein Size: 218

Molecular Weight: 24 kDa

Gene ID: 581

NCBI Accession: NM_004324, NP_004315

UniProt: Q07812

Pathways: p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response