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Presenilin 2 antibody (C-Term)

This anti-Presenilin 2 antibody is a Rabbit Polyclonal antibody detecting Presenilin 2 in WB. Suitable for Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Saccharomyces cerevisiae.
Catalog No. ABIN2787885

Quick Overview for Presenilin 2 antibody (C-Term) (ABIN2787885)

Target

See all Presenilin 2 (PSEN2) Antibodies
Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivity

  • 59
  • 44
  • 33
  • 6
  • 5
  • 4
  • 4
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host

  • 52
  • 4
  • 3
  • 2
  • 2
Rabbit

Clonality

  • 58
  • 5
Polyclonal

Conjugate

  • 39
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Presenilin 2 antibody is un-conjugated

Application

  • 52
  • 21
  • 18
  • 13
  • 12
  • 10
  • 3
  • 3
  • 3
  • 3
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 15
    • 9
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Sequence

    PYDPEMEEDS YDSFGEPSYP EVFEPPLTGY PGEELEEEEE RGVKLGLGDF

    Predicted Reactivity

    Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%, Zebrafish: 100%

    Characteristics

    This is a rabbit polyclonal antibody against PSEN2. It was validated on Western Blot.

    Purification

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the C-terminal region of human PSEN2
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeat freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

    Alternative Name

    PSEN2

    Background

    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
    Alias Symbols: AD4, PS2, AD3L, STM2, CMD1V
    Protein Size: 304

    Molecular Weight

    33 kDa

    Gene ID

    5664

    NCBI Accession

    XM_011544236, XP_011542538

    UniProt

    E5RG63

    Pathways

    Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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