CD22 antibody (N-Term)

Catalog No. ABIN2788241

Product Details anti-CD22 Antibody

Target: CD22 (CD22 Molecule (CD22))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD22 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TYRALDGDLE SFILFHNPEY NKNTSKFDGT RLYESTKDGK VPSEQKRVQF

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CD22. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CD22

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 847 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CD22

Target: CD22 (CD22 Molecule (CD22))

Alternative Name: CD22 (CD22 Products)

Synonyms: A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody

Background: CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Alias Symbols: FLJ22814, MGC130020, SIGLEC-2, SIGLEC2
Protein Interaction Partner: UBC, CD19, INPP5D, LCP2, AP2M1, SHC1, SYK, PTPN6, PLCG1, PIK3R1, LYN, PTPRC, IGHM, HP, ST6GAL1, ATP2B4, GRB2, AP2A1,
Protein Size: 847

Molecular Weight: 95 kDa

Gene ID: 933

NCBI Accession: NM_001771, NP_001762

UniProt: P20273