F2RL1 antibody (C-Term)

Catalog No. ABIN2788314

There is 1 publication for this product available. The Rabbit Polyclonal anti-F2RL1 antibody is suitable to detect F2RL1 in samples from Human, Rat, Dog and Guinea Pig. It has been validated for WB.

Quick Overview for F2RL1 antibody (C-Term) (ABIN2788314)

Target: F2RL1 (Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1))

Reactivity: Human, Rat, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This F2RL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-F2RL1 Antibody

Binding Specificity: C-Term

Purpose: F2RL1 Antibody - C-terminal region

Sequence: VSHDFRDHAK NALLCRSVRT VKQMQVSLTS KKHSRKSSSY SSSSTTVKTS

Predicted Reactivity: Dog: 93%, Guinea Pig: 86%, Human: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against F2RL1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60034-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-F2RL1 antibody (ABIN2788314)

Yau, Liu, Fairlie: "Toward drugs for protease-activated receptor 2 (PAR2)." in: Journal of medicinal chemistry, Vol. 56, Issue 19, pp. 7477-97, (2013) (PubMed).

Target Details for F2RL1

Target: F2RL1 (Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1))

Alternative Name: F2RL1

Background:

Background Information: Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83 % identical to the mouse receptor sequence.

Gene Name: Coagulation factor II (thrombin) receptor-like 1

Alternative Symbols: PAR2, GPR11

Protein Name: Proteinase-activated receptor 2

Molecular Weight: 44kDa

Gene ID: 2150

NCBI Accession: NP_005233

UniProt: P55085

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome