Factor VII antibody (Middle Region)

Catalog No. ABIN2788317

This Rabbit Polyclonal antibody specifically detects Factor VII in WB. It exhibits reactivity toward Human, Rat, Cow, Rabbit, Pig and Horse.

Quick Overview for Factor VII antibody (Middle Region) (ABIN2788317)

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Reactivity: Human, Rat, Cow, Rabbit, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Factor VII antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Factor VII Antibody

Binding Specificity: Middle Region

Purpose: F7 Antibody - middle region

Sequence: RCHEGYSLLA DGVSCTPTVE YPCGKIPILE KRNASKPQGR IVGGKVCPKG

Predicted Reactivity: Cow: 86%, Horse: 86%, Human: 100%, Pig: 79%, Rabbit: 85%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against F7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human F7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60039-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Factor VII

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Alternative Name: F7

Background:

Background Information: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.

Gene Name: Coagulation factor VII (serum prothrombin conversion accelerator)

Alternative Symbols: SPCA

Protein Name: Coagulation factor VII

Molecular Weight: 52kDa

Gene ID: 2155

NCBI Accession: NP_000122

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling