PFKM antibody (C-Term)

Catalog No. ABIN2788704

This Rabbit Polyclonal antibody specifically detects PFKM in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio) and Cow.

Quick Overview for PFKM antibody (C-Term) (ABIN2788704)

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio), Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKM antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PFKM Antibody

Binding Specificity: C-Term

Sequence: RALVFQPVAE LKDQTDFEHR IPKEQWWLKL RPILKILAKY EIDLDTSDHA

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against PFKM. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PFKM

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 780 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PFKM

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Alternative Name: PFKM

Background: Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.
Alias Symbols: GSD7, MGC8699, PFK-1, PFK1, PFKA, PFKX
Protein Interaction Partner: UBC, SIAH1, PFKM, SUMO2, EGFR, DCP2, DCP1A, TUBB2A, PFKP, PCBP1, UBTD1, FBXO6, LSM7, PFKL, NDUFB2, Hoxa1, CUL3, MAPK3, PCNA, SUMO1, ATP6V0A4, FHL2, DYNLL1, CAV3, NOS1, HGS,
Protein Size: 780

Molecular Weight: 85 kDa

Gene ID: 5213

NCBI Accession: NM_000289, NP_000280

UniProt: P08237

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Warburg Effect