S100A8 antibody (Middle Region)

Catalog No. ABIN786406

This Rabbit Polyclonal antibody specifically detects S100A8 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for S100A8 antibody (Middle Region) (ABIN786406)

Target: S100A8 (S100 Calcium Binding Protein A8 (S100A8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S100A8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-S100A8 Antibody

Binding Specificity: Middle Region

Sequence: QYIRKKGADV WFKELDINTD GAVNFQEFLI LVIKMGVAAH KKSHEESHKE

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against S100A8. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 93 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for S100A8

Target: S100A8 (S100 Calcium Binding Protein A8 (S100A8))

Alternative Name: S100A8

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
Alias Symbols: 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8
Protein Interaction Partner: NCF2, TUBGCP3, SUMO2, S100A8, BECN1, BAG3, SRP1, SEC27, CDC34, CDC53, TRAF3IP1, PAXIP1, ESR1, APP, SHC1, COPS5, TFAP4, CDK2, SIRT7, UBC, CDKN1A, POT1, TERF2, TERF1, S100A9, SLX1B, DMWD, PDCD11, LRIF1, CEACAM3, KLC2, RAB17, IGSF21, CHGB, C14orf1, UNC119, P
Protein Size: 93

Molecular Weight: 10 kDa

Gene ID: 6279

NCBI Accession: NM_002964, NP_002955

UniProt: P05109

Pathways: Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins