RPS6 antibody (C-Term)

Catalog No. ABIN2788795

The Rabbit Polyclonal anti-RPS6 antibody has been validated for WB. It is suitable to detect RPS6 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Horse, Goat and Guinea Pig.

Quick Overview for RPS6 antibody (C-Term) (ABIN2788795)

Target: RPS6 (Ribosomal Protein S6 (RPS6))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Horse, Goat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RPS6 Antibody

Binding Specificity: C-Term

Sequence: KKNKEEAAEY AKLLAKRMKE AKEKRQEQIA KRRRLSSLRA STSKSESSQK

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against RPS6. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 249 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RPS6

Target: RPS6 (Ribosomal Protein S6 (RPS6))

Alternative Name: RPS6

Background: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Alias Symbols: S6
Protein Interaction Partner: MDM2, CEP250, TUBGCP3, VCP, TUBG1, TP53, SUMO2, UIMC1, STAU1, UBC, rev, HNRNPU, FAU, EIF3CL, WIBG, WDR26, PNO1, RPS29, RPS28, RPS27, RPS26, RPS25, RPS24, RPS23, RPS20, RPS19, RPS18, RPS16, RPS15A, RPS14, RPS13, RPS12, RPS10, RPS9, RPS8, RPS7, RPS5, RPS4X,
Protein Size: 249

Molecular Weight: 27 kDa

Gene ID: 6194

NCBI Accession: NM_001010, NP_001001

UniProt: P62753

Pathways: Carbohydrate Homeostasis, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly