GIT2 antibody (C-Term)

Catalog No. ABIN2788863

The Rabbit Polyclonal anti-GIT2 antibody (ABIN2788863) specifically detects GIT2 in WB. The antibody is reactive with Human, Rat, Dog, Cow, Horse, Pig, Guinea Pig and Rabbit samples.

Quick Overview for GIT2 antibody (C-Term) (ABIN2788863)

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Reactivity: Human, Rat, Dog, Cow, Horse, Pig, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GIT2 Antibody

Binding Specificity: C-Term

Purpose: GIT2 Antibody - C-terminal region

Sequence: VQTGSEYTDT SNHSSLKRRP SARGSRPMSM YETGSGQKPY LPMGEASRPE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Pig: 100%, Rabbit: 93%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against GIT2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61662-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GIT2

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Alternative Name: GIT2

Background:

Background Information: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined.

Gene Name: G protein-coupled receptor kinase interacting ArfGAP 2

Alternative Symbols: PKL, CAT2, CAT-2

Protein Name: ARF GTPase-activating protein GIT2

Molecular Weight: 83kDa

Gene ID: 9815

NCBI Accession: NP_476510

UniProt: Q14161

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling