Cullin 4B antibody (C-Term)

Catalog No. ABIN2789003

The Rabbit Polyclonal anti-Cullin 4B antibody (ABIN2789003) specifically detects Cullin 4B in WB. The antibody is reactive with Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Horse, Rabbit, Guinea Pig and Goat samples.

Quick Overview for Cullin 4B antibody (C-Term) (ABIN2789003)

Target: Cullin 4B (CUL4B)

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Horse, Rabbit, Guinea Pig, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cullin 4B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Cullin 4B Antibody

Binding Specificity: C-Term

Purpose: Cul4b Antibody - C-terminal region

Sequence: IQMKETVEEQ ASTTERVFQD RQYQIDAAIV RIMKMRKTLS HNLLVSEVYN

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Cul4b. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62057-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Cullin 4B

Target: Cullin 4B (CUL4B)

Alternative Name: Cul4b

Background:

Background Information: Cul4b is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.

Gene Name: Cullin 4B

Alternative Symbols: CUL-4B, AA409770, mKIAA0695, 2700050M05Rik

Protein Name: Cullin-4B

Molecular Weight: 111kDa

Gene ID: 72584

NCBI Accession: NP_001103612

UniProt: A2A432