TSEN2 antibody (C-Term)

Catalog No. ABIN2789135

The Rabbit Polyclonal anti-TSEN2 antibody (ABIN2789135) specifically detects TSEN2 in WB. The antibody is reactive with Human, Dog, Horse, Rabbit, Cow, Guinea Pig and Pig samples.

Quick Overview for TSEN2 antibody (C-Term) (ABIN2789135)

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Reactivity: Human, Dog, Horse, Rabbit, Cow, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSEN2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TSEN2 Antibody

Binding Specificity: C-Term

Purpose: TSEN2 Antibody - C-terminal region

Sequence: LRRPLSWKSL AALSRVSVNV SKELMLCYLI KPSTMTDKEM ESPECMKRIK

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Pig: 93%, Rabbit: 86%

Characteristics: This is a rabbit polyclonal antibody against TSEN2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62409-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TSEN2

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Alternative Name: TSEN2

Background:

Targeted Subunit: Sen2

Background Information: This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: TRNA splicing endonuclease 2 homolog (S. cerevisiae)

Alternative Symbols: SEN2, PCH2B, SEN2L

Protein Name: tRNA-splicing endonuclease subunit Sen2

Molecular Weight: 51kDa

Gene ID: 80746

NCBI Accession: NP_079541

UniProt: Q8NCE0

Pathways: Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha