Poliovirus Receptor antibody (N-Term)

Catalog No. ABIN2789343

Product Details anti-Poliovirus Receptor Antibody

Target: Poliovirus Receptor (PVR)

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Poliovirus Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: FHQTQGPSYS ESKRLEFVAA RLGAELRNAS LRMFGLRVED EGNYTCLFVT

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against PVR. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 417 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Poliovirus Receptor

Target: Poliovirus Receptor (PVR)

Alternative Name: PVR (PVR Products)

Synonyms: PVR antibody, CD155 antibody, HVED antibody, NECL5 antibody, Necl-5 antibody, PVS antibody, TAGE4 antibody, 3830421F03Rik antibody, D7Ertd458e antibody, Taa1 antibody, Tage4 antibody, mE4 antibody, necl-5 antibody, poliovirus receptor antibody, PVR antibody, Pvr antibody

Background: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CD155, FLJ25946, HVED, NECL5, Necl-5, PVS, TAGE4
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-8, KRTAP10-9, KRTAP10-7, SLC30A2, TIGIT, TNFRSF12A, WNK1, PLA2G3, UBC, ZC3HAV1, ELAVL1, CD226, PVRL3, PVRL1, CD96, AP1M2, DYNLT3, VTN, PVR, DYNLT1,
Protein Size: 417

Molecular Weight: 45 kDa

Gene ID: 5817

NCBI Accession: NM_006505, NP_006496

UniProt: P15151

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome