TPMT antibody (C-Term)

Catalog No. ABIN2789428

Product Details anti-TPMT Antibody

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Binding Specificity: C-Term

Reactivity: Human, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPMT antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RGALVAINPG DRKCYADTMF SLLGKKFQYL LCVLSYDPTK HPGPPFYVPH

Predicted Reactivity: Dog: 79%, Human: 100%, Pig: 79%

Characteristics: This is a rabbit polyclonal antibody against TPMT. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 245 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Alternative Name: TPMT (TPMT Products)

Background: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Alias Symbols: -
Protein Interaction Partner: APP, UBC,
Protein Size: 245

Molecular Weight: 27 kDa

Gene ID: 7172

NCBI Accession: NM_000367, NP_000358

UniProt: P51580