ARHGEF1 antibody (N-Term)

Catalog No. ABIN2789444

The Rabbit Polyclonal anti-ARHGEF1 antibody (ABIN2789444) specifically detects ARHGEF1 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse and Pig samples.

Quick Overview for ARHGEF1 antibody (N-Term) (ABIN2789444)

Target: ARHGEF1 (rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ARHGEF1 Antibody

Binding Specificity: N-Term

Sequence: SAAVVNAIGL YMRHLGVRTK SGDKKSGRNF FRKKVMGNRR SDEPAKTKKG

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ARHGEF1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ARHGEF1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 912 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ARHGEF1

Target: ARHGEF1 (rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1))

Alternative Name: ARHGEF1

Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Alias Symbols: GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5
Protein Interaction Partner: TCF4, UBC, CYFIP1, CAP2, FN1, DCUN1D1, SH3KBP1, CSNK1E, SREBF2, MEPCE, TAF10, CNKSR1, GNA13, ARHGEF1, PRKCA, CD44, RAP1A, HRAS, PIK3CA, RHOA, GNA12, ATR,
Protein Size: 912

Molecular Weight: 102 kDa

Gene ID: 9138

NCBI Accession: NM_199002, NP_945353

UniProt: Q92888

Pathways: Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling