SCG5 antibody (C-Term)

Catalog No. ABIN2789642

Product Details anti-SCG5 Antibody

Target: SCG5 (Secretogranin V (7B2 Protein) (SCG5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Pig, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCG5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QHLFDPEHDY PGLGKWNKKL LYEKMKGGER RKRRSVNPYL QGQRLDNVVA

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SCG5. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 212 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SCG5

Target: SCG5 (Secretogranin V (7B2 Protein) (SCG5))

Alternative Name: SCG5 (SCG5 Products)

Synonyms: zgc:73132 antibody, sgne1 antibody, MGC145087 antibody, 7B2 antibody, AI325031 antibody, Sgne-1 antibody, Sgne1 antibody, P7B2 antibody, SGNE1 antibody, SgV antibody, secretogranin V antibody, scg5 antibody, SCG5 antibody, Scg5 antibody

Background: SCG5 acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. SCG5 binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. SCG5 is also required for cleavage of PCSK2 but does not appear to be involved in its folding. SCG5 plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Alias Symbols: 7B2, P7B2, SGNE1, SgV
Protein Interaction Partner: UBQLN1, KHDRBS1, UBQLN4, NR1H2, PCSK2,
Protein Size: 212

Molecular Weight: 23 kDa

Gene ID: 6447

NCBI Accession: NM_001144757, NP_001138229

UniProt: P05408