SCG5 antibody (N-Term)

Catalog No. ABIN2789643

The Rabbit Polyclonal anti-SCG5 antibody (ABIN2789643) specifically detects SCG5 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for SCG5 antibody (N-Term) (ABIN2789643)

Target: SCG5 (Secretogranin V (7B2 Protein) (SCG5))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCG5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SCG5 Antibody

Binding Specificity: N-Term

Purpose: SCG5 Antibody - N-terminal region

Sequence: GPQSIEGGAH EGLQHLGPFG NIPNIVAELT GDNIPKDFSE DQGYPDPPNP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against SCG5. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63847-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SCG5

Target: SCG5 (Secretogranin V (7B2 Protein) (SCG5))

Alternative Name: SCG5

Background:

Background Information: SCG5 acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. SCG5 binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. SCG5 is also required for cleavage of PCSK2 but does not appear to be involved in its folding. SCG5 plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene Name: Secretogranin V (7B2 protein)

Alternative Symbols: 7B2, SgV, P7B2, SGNE1

Protein Name: Neuroendocrine protein 7B2

Molecular Weight: 23kDa

Gene ID: 6447

NCBI Accession: NP_001138229

UniProt: P05408