MCPH1 antibody (C-Term)

Catalog No. ABIN2789647

Product Details anti-MCPH1 Antibody

Target: MCPH1 (Microcephalin 1 (MCPH1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCPH1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VLDDSCDGFK DLIKPHEELK KSGRGKKPTR TLVMTSMPSE KQNVVIQVVD

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against MCPH1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 835 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MCPH1

Target: MCPH1 (Microcephalin 1 (MCPH1))

Alternative Name: MCPH1 (MCPH1 Products)

Synonyms: RGD1560642 antibody, MGC83773 antibody, MCPH1 antibody, mct antibody, brit1 antibody, MGC148665 antibody, BRIT1 antibody, MCT antibody, 5430437K10Rik antibody, D030046N04Rik antibody, microcephalin 1 antibody, microcephalin 1 S homeolog antibody, microcephaly, primary autosomal recessive 1 antibody, Mcph1 antibody, mcph1.S antibody, MCPH1 antibody, mcph1 antibody

Background: This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome.
Alias Symbols: BRIT1, FLJ12847, MCT
Protein Interaction Partner: KDM1A, PHF11, TADA2A, ABCC2, E2F1, CDC27, CHD4, H2AFX, CHEK1, MDC1, TP53BP1, SMARCC2, SMARCC1, SMARCB1, SMARCA4, SMARCA2, RAD51, NBN, MCM2, BRCA2, ATR, ATM, RPA1,
Protein Size: 835

Molecular Weight: 93 kDa

Gene ID: 79648

NCBI Accession: NM_024596, NP_078872

UniProt: Q8NEM0

Pathways: Stem Cell Maintenance