Integrin Alpha2b antibody (N-Term)

Catalog No. ABIN2789680

This anti-Integrin Alpha2b antibody is a Rabbit Polyclonal antibody detecting Integrin Alpha2b in WB. Suitable for Human, Mouse, Rat, Dog, Guinea Pig, Pig, Rabbit, Saccharomyces cerevisiae and Horse.

Quick Overview for Integrin Alpha2b antibody (N-Term) (ABIN2789680)

Target: Integrin Alpha2b (CD41)

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Pig, Rabbit, Saccharomyces cerevisiae, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin Alpha2b antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Integrin Alpha2b Antibody

Binding Specificity: N-Term

Sequence: QGLGASVVSW SDVIVACAPW QHWNVLEKTE EAEKTPVGSC FLAQPESGRR

Predicted Reactivity: Dog: 100%, Guinea Pig: 86%, Horse: 92%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 85%, Rat: 92%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against ITGA2B. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1039 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: ITGA2B

Background: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Alias Symbols: CD41, CD41B, GP2B, GPIIb, GTA, HPA3, GT, BDPLT2
Protein Interaction Partner: FBXO6, PRKACA, CAMK2A, ITGA2B, AUP1, CIB1, CLNS1A, VWF, TLN1, F2, CD36, ITGB3, FGA, COL1A2, COL2A1, CALR, GRB2, RNF181,
Protein Size: 1039

Molecular Weight: 16 kDa

Gene ID: 3674

NCBI Accession: NM_000419, NP_000410

UniProt: P08514

Pathways: Integrin Complex