GPBAR1 antibody (C-Term)

Catalog No. ABIN2789752

The Rabbit Polyclonal anti-GPBAR1 antibody is suitable to detect GPBAR1 in samples from Human and Rat. It has been validated for WB.

Quick Overview for GPBAR1 antibody (C-Term) (ABIN2789752)

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPBAR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GPBAR1 Antibody

Binding Specificity: C-Term

Purpose: GPBAR1 Antibody - C-terminal region

Sequence: AAAVPVAMGL GDQRYTAPWR AAAQRCLQGL WGRASRDSPG PSIAYHPSSQ

Predicted Reactivity: Human: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GPBAR1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64154-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GPBAR1

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Alternative Name: GPBAR1

Background:

Background Information: This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.

Gene Name: G protein-coupled bile acid receptor 1

Alternative Symbols: BG37, TGR5, M-BAR, GPCR19, GPR131

Protein Name: G-protein coupled bile acid receptor 1

Molecular Weight: 35kDa

Gene ID: 151306

NCBI Accession: NP_733800

UniProt: Q8TDU6

Pathways: WNT Signaling, Hormone Transport, Sensory Perception of Sound