TNK1 antibody (C-Term)

Catalog No. ABIN2790058

The Rabbit Polyclonal anti-TNK1 antibody is suitable to detect TNK1 in samples from Human, Guinea Pig, Pig, Rabbit and Saccharomyces cerevisiae. It has been validated for WB.

Quick Overview for TNK1 antibody (C-Term) (ABIN2790058)

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Reactivity: Human, Guinea Pig, Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TNK1 Antibody

Binding Specificity: C-Term

Purpose: TNK1 Antibody - C-terminal region

Sequence: EIRQARAVPQ GPPGLPPRPP LSSSSPQPSQ PSRERLPWPK RKPPHNHPMG

Predicted Reactivity: Guinea Pig: 83%, Human: 100%, Pig: 85%, Rabbit: 77%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against TNK1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP65151-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNK1

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Alternative Name: TNK1

Background:

Background Information: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: Tyrosine kinase, non-receptor, 1

Alternative Symbols: KOS1

Protein Name: Non-receptor tyrosine-protein kinase TNK1

Molecular Weight: 72kDa

Gene ID: 8711

NCBI Accession: NP_003976

UniProt: Q13470