SELPLG antibody (C-Term)

Catalog No. ABIN2790195

This Rabbit Polyclonal antibody specifically detects SELPLG in WB. It exhibits reactivity toward Human, Rat, Cow, Dog and Guinea Pig.

Quick Overview for SELPLG antibody (C-Term) (ABIN2790195)

Target: SELPLG (Selectin P Ligand (SELPLG))

Reactivity: Human, Rat, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SELPLG antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SELPLG Antibody

Binding Specificity: C-Term

Purpose: SELPLG Antibody - C-terminal region

Sequence: EMVCISSLLP DGGEGPSATA NGGLSKAKSP GLTPEPREDR EGDDLTLHSF

Predicted Reactivity: Cow: 91%, Dog: 83%, Guinea Pig: 92%, Human: 100%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against SELPLG. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SELPLG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP65609-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SELPLG

Target: SELPLG (Selectin P Ligand (SELPLG))

Alternative Name: SELPLG

Background:

Background Information: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

Gene Name: Selectin P ligand

Alternative Symbols: CLA, CD162, PSGL1, PSGL-1

Protein Name: P-selectin glycoprotein ligand 1

Molecular Weight: 39kDa

Gene ID: 6404

NCBI Accession: NP_002997

UniProt: Q14242