HSPD1 antibody (C-Term)

Catalog No. ABIN2792215

The Rabbit Polyclonal anti-HSPD1 antibody (ABIN2792215) specifically detects HSPD1 in WB. The antibody is reactive with Human, Rat, Rabbit and Guinea Pig samples.

Quick Overview for HSPD1 antibody (C-Term) (ABIN2792215)

Target: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Reactivity: Human, Rat, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSPD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HSPD1 Antibody

Binding Specificity: C-Term

Purpose: HSPD1 Antibody - C-terminal region

Sequence: PTKVVRTALL DAAGVASLLT TAEVVVTEIP KEEKDPGMGA MGGMGGGMGG

Predicted Reactivity: Guinea Pig: 90%, Human: 84%, Rabbit: 84%, Rat: 84%

Characteristics: This is a rabbit polyclonal antibody against HSPD1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HSPD1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HSPD1

Target: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Alternative Name: HSPD1

Background:

Background Information: HSPD1 is a member of the chaperonin family. This mitochondrial protein may function as a signaling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.

Gene Name: Heat shock 60 kDa protein 1 (chaperonin)

Alternative Symbols: HLD4, CPN60, GROEL, HSP60, HSP65, SPG13, HSP-60, HuCHA60

Protein Name: 60 kDa heat shock protein, mitochondrial

Molecular Weight: 61kDa

Gene ID: 3329

NCBI Accession: NP_002147

UniProt: P10809

Pathways: Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity