CHRNA9 antibody (N-Term)

Catalog No. ABIN2792251

This Rabbit Polyclonal antibody specifically detects CHRNA9 in WB. It exhibits reactivity toward Mouse, Dog, Cow, Horse, Rabbit, Guinea Pig and Zebrafish (Danio rerio).It has been mentioned in 1 publication

Quick Overview for CHRNA9 antibody (N-Term) (ABIN2792251)

Target: CHRNA9 (Cholinergic Receptor, Nicotinic, alpha 9 (Neuronal) (CHRNA9))

Reactivity: Mouse, Dog, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA9 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CHRNA9 Antibody

Binding Specificity: N-Term

Purpose: CHRNA9 Antibody - N-terminal region

Sequence: MNWSHSCISF CWIYFAASRL RAAETADGKY AQKLFNDLFE DYSNALRPVE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Mouse: 93%, Rabbit: 100%, Zebrafish: 80%

Characteristics: This is a rabbit polyclonal antibody against CHRNA9. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHRNA9

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CHRNA9 antibody (ABIN2792251)

Guha, Bandyopadhyaya, Polumuri, Chumsri, Gade, Kalvakolanu, Ahmed et al.: "Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic ..." in: Breast cancer research and treatment, Vol. 145, Issue 1, pp. 5-22, (2014) (PubMed).

Target Details for CHRNA9

Target: CHRNA9 (Cholinergic Receptor, Nicotinic, alpha 9 (Neuronal) (CHRNA9))

Alternative Name: CHRNA9

Background:

Targeted Subunit: alpha-9

Background Information: CHRNA9 is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor superfamily. CHRNA9 is a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. It is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea.This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.

Gene Name: Cholinergic receptor, nicotinic, alpha 9 (neuronal)

Alternative Symbols: NACHRA9, HSA243342

Protein Name: Neuronal acetylcholine receptor subunit alpha-9

Molecular Weight: 55 kDa

Gene ID: 55584

NCBI Accession: NP_060051

UniProt: Q9UGM1

Pathways: Sensory Perception of Sound