VEGFR2/CD309 antibody (N-Term)

Catalog No. ABIN2792307

The Rabbit Polyclonal anti-VEGFR2/CD309 antibody has been validated for WB and IHC. It is suitable to detect VEGFR2/CD309 in samples from Human, Pig, Dog, Cow and Horse.

Quick Overview for VEGFR2/CD309 antibody (N-Term) (ABIN2792307)

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Reactivity: Human, Pig, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFR2/CD309 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-VEGFR2/CD309 Antibody

Binding Specificity: N-Term

Sequence: LNVGIDFNWE YPSSKHQHKK LVNRDLKTQS GSEMKKFLST LTIDGVTRSD

Predicted Reactivity: Cow: 86%, Dog: 100%, Horse: 100%, Human: 100%, Pig: 100%

Characteristics: This is a rabbit polyclonal antibody against KDR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KDR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1356 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for VEGFR2/CD309

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Alternative Name: KDR

Background: KDR is the receptor for VEGF or VEGFC. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Alias Symbols: CD309, FLK1, VEGFR, VEGFR2
Protein Interaction Partner: FBXO25, VEGFA, MYO1C, CAV1, NPM1, EPN1, SRC, CBL, IQGAP1, UBC, CSNK1D, FBXW11, BTRC, CUL1, AIMP2, SHC2, SYNGAP1, ACP1, ATR, FRS2, SH2D2A, DNM2, NRP1, VEGFC, GRB10, CDH5, GNAQ, SHC1, STAT1, NCK1, SHB, PLCG2, P2RY2, BMX, FIGF, KDR, TIMP3, PTPN6, PTPN11, ITG
Protein Size: 1356

Molecular Weight: 151 kDa

Gene ID: 3791

NCBI Accession: NM_002253, NP_002244

UniProt: P35968

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling