MAP3K4 antibody (AA 235-264)

Catalog No. ABIN2793281

The Rabbit Polyclonal anti-MAP3K4 antibody has been validated for IHC and WB. It is suitable to detect MAP3K4 in samples from Human.

Quick Overview for MAP3K4 antibody (AA 235-264) (ABIN2793281)

Target: MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-MAP3K4 Antibody

Binding Specificity: AA 235-264

Purpose: Rabbit Anti-Human MEKK4 (MAP2K4) (S257) Antibody

Immunogen: This MEKK4(MAP2K4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from human MEKK4(MAP2K4).

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50Western blot analysis of MAP2K4 (arrow) using rabbit polyclonal MAP2K4 Antibody (S257) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.350 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for MAP3K4

Target: MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))

Alternative Name: MEKK4

Background:

Target Description: MAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

Gene Symbol: MAP2K4

Molecular Weight: 44288 Da

Gene ID: 6416

UniProt: P45985

Pathways: MAPK Signaling