Caspase 8 antibody (C-Term)

Catalog No. ABIN2794942

This Rabbit Polyclonal antibody specifically detects Caspase 8 in WB, IHC, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for Caspase 8 antibody (C-Term) (ABIN2794942)

Target: Caspase 8 (CASP8)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-Caspase 8 Antibody

Binding Specificity: AA 432-461, C-Term

Purpose: Rabbit Anti-Human CASP8 (C-term) Antibody

Immunogen: This CASP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human CASP8.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry, Flow Cytometry, Immunofluorescence
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50, FC: 1:10-50, IF: 1:10-50Western blot analysis of CASP8 antibody (C-term) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.0 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for Caspase 8

Target: Caspase 8 (CASP8)

Alternative Name: CASP8

Background:

Target Description: CASP8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases.

Gene Symbol: CASP8

Molecular Weight: 55391 Da

Gene ID: 841

UniProt: Q14790

Pathways: Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades