SGOL2 antibody (Center)

Catalog No. ABIN2795993

The Rabbit Polyclonal anti-SGOL2 antibody has been validated for WB. It is suitable to detect SGOL2 in samples from Human.

Quick Overview for SGOL2 antibody (Center) (ABIN2795993)

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGOL2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SGOL2 Antibody

Binding Specificity: AA 391-419, Center

Purpose: Rabbit Anti-Human SGOL2 (Center) Antibody

Immunogen: This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000SGOL2 Antibody (Center) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for SGOL2

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Alternative Name: SGOL2

Background:

Target Description: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Gene Symbol: SGOL2

Molecular Weight: 144739 Da

Gene ID: 151246

UniProt: Q562F6