APBB2 antibody (AA 251-350) (Alexa Fluor 594)

Catalog No. ABIN2809806

Product Details anti-APBB2 Antibody (Alexa Fluor 594)

Target: APBB2 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2))

Binding Specificity: AA 251-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APBB2 antibody is conjugated to Alexa Fluor 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APBB2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for APBB2

Target: APBB2 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2))

Alternative Name: APBB2/FE65L1 (APBB2 Products)

Synonyms: FE65L antibody, FE65L1 antibody, 2310007D03Rik antibody, Rirl1 antibody, TR2L antibody, Zfra antibody, RGD1562438 antibody, APBB2 antibody, fe65l antibody, fe65l1 antibody, DKFZp469I236 antibody, si:ch211-201g8.2 antibody, amyloid beta precursor protein binding family B member 2 antibody, amyloid beta (A4) precursor protein-binding, family B, member 2 antibody, amyloid beta (A4) precursor protein-binding, family B, member 2b antibody, APBB2 antibody, Apbb2 antibody, apbb2 antibody, apbb2b antibody

Background:

Synonyms: Amyloid beta A4 precursor protein-binding, family B, member 2 Fe65 like, Amyloid beta A4 precursor protein binding family B member 2, Amyloid beta A4 precursor protein-binding family B member 2, APBB 2, APBB2, APBB2_HUMAN, Fe65 like 1, Fe65 like, Fe65 like protein, FE65L 1, FE65L, FE65L1, Protein Fe65-like 1, Rirl 1, Rirl1, TR2 L, TR2L, Zfra, Zinc finger like protein.

Background: Fe65L is a 758 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the -Amyloid precursor protein, Fe65L is thought to modulate the internalization and, therefore, the accessibility and function of -Amyloid. Via its ability to control the intracellular accumulation of -Amyloid, Fe65L is thought to play a role in the pathogenesis of Alzheimer's disease. Multiple isoforms of Fe65L exist due to alternative splicing events. The gene encoding Fe65L maps to human chromosome 4, which encodes nearly 6 % of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.