RUVBL1 antibody

Catalog No. ABIN2837838

Product Details anti-RUVBL1 Antibody

Target: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RUVBL1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified His-tagged RUVBL1 protein(Fragment) was used to produced this monoclonal antibody.

Clone: 507CT2-2-2

Isotype: IgG1

Application Details

Application Notes: WB: 1:100~500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: RUVBL1 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for RUVBL1

Target: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Alternative Name: RUVBL1 (RUVBL1 Products)

Synonyms: rvb1 antibody, ecp54 antibody, tip49 antibody, nmp238 antibody, pontin antibody, tip49a antibody, xpontin antibody, pontin52 antibody, TIP49 antibody, wu:fd18e04 antibody, zpontin antibody, ECP54 antibody, INO80H antibody, NMP238 antibody, PONTIN antibody, Pontin52 antibody, RVB1 antibody, TIH1 antibody, TIP49A antibody, Tip49a antibody, 2510009G06Rik antibody, RuvB like AAA ATPase 1 antibody, RuvB-like 1 (E. coli) antibody, RuvB-like 1 antibody, RuvB like AAA ATPase 1 S homeolog antibody, RuvB-like AAA ATPase 1 antibody, RuvB-like protein 1 antibody, RUVBL1 antibody, ruvbl1 antibody, PVX_123295 antibody, Bm1_15605 antibody, ruvb1 antibody, ruvbl1.S antibody, Ruvbl1 antibody

Background: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation.

Molecular Weight: 50228

Gene ID: 8607

NCBI Accession: NP_003698

UniProt: Q9Y265

Pathways: Telomere Maintenance